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Pharmacogenomics as a Tool for Management of Drug Hypersensitivity Reactions

Authors
  • Pérez-Sánchez, Natalia1
  • Jurado-Escobar, Raquel2
  • Doña, Inmaculada1, 3
  • Soriano-Gomis, Víctor4, 5
  • Moreno-Aguilar, Carmen6, 7, 8
  • Bartra, Joan9, 10
  • Isidoro-García, María11, 12, 13
  • Torres, María José1, 3
  • Cornejo-García, José Antonio2, 3
  • 1 UMA, Allergy Unit, IBIMA, Regional University Hospital of Malaga, Malaga, Spain , Malaga (Spain)
  • 2 UMA, Research Laboratory, IBIMA, Regional University Hospital of Malaga, Plaza del Hospital Civil s/n, Hospital Civil, Pabellón 6, 1ª planta, Málaga, 29009, Spain , Málaga (Spain)
  • 3 Carlos III Health Institute, ARADyAL Network RD16/0006/0001, Malaga, Spain , Malaga (Spain)
  • 4 Hospital General Universitario de Alicante, Alicante, Spain , Alicante (Spain)
  • 5 Carlos III Health Institute, ARADyAL Network RD16/0006/0032, Alicante, Spain , Alicante (Spain)
  • 6 Reina Sofia University Hospital, Allergy Service, Cordoba, Spain , Cordoba (Spain)
  • 7 Maimonides Institute for Research in Biomedicine (IMIBIC), Cordoba, Spain , Cordoba (Spain)
  • 8 Carlos III Health Institute, ARADyAL Network RD16/0006/0018, Cordoba, Spain , Cordoba (Spain)
  • 9 Hospital Clínic Universitat de Barcelona, Allergy Section, Pneumology Department, Barcelona, Spain , Barcelona (Spain)
  • 10 Carlos III Health Institute, ARADyAL Network RD16/0006/0007, Barcelona, Spain , Barcelona (Spain)
  • 11 University of Salamanca, Biosciences Institute of Salamanca, Salamanca, Spain , Salamanca (Spain)
  • 12 University of Salamanca, Department of Medicine, Salamanca, Spain , Salamanca (Spain)
  • 13 Carlos III Health Institute, ARADyAL Network RD16/0006/0019, Salamanca, Spain , Salamanca (Spain)
Type
Published Article
Journal
Current Treatment Options in Allergy
Publisher
Springer International Publishing
Publication Date
Jan 18, 2019
Volume
6
Issue
1
Pages
1–17
Identifiers
DOI: 10.1007/s40521-019-0199-3
Source
Springer Nature
Keywords
License
Yellow

Abstract

Purpose of reviewDrug hypersensitivity reactions constitute an unpredictable, serious problem for health care systems as they interfere with drug treatment, limit therapeutic options, and may be life-threatening. In addition to specific patient factors, they are also influenced by a genetic component. Indeed, a considerable body of knowledge supports the participation of genetic variants in their underlying mechanisms.Recent findingsLatest research on this topic confirms the involvement of specific HLA alleles in non-immediate reactions. Two well-known examples are the HLA-B*58:01 allele in severe allopurinol-triggered reactions, and the HLA-B*15:02 allele in carbamazepine-induced Stevens-Johnson syndrome/toxic epidermal necrolysis. However, there is a lack of reliable genetic markers for immediate reactions and for hypersensitivity to NSAIDs.SummaryWe summarize available information on the genetics of drug hypersensitivity reactions, highlighting regulatory agencies recommendations when available. We include some comments about new technological tools that should be implemented in the study of these reactions.

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