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[Pharmacogenetics for patient care in France: A discipline that evolves!]

Authors
  • Barin-Le Guellec, Chantal1
  • Picard, Nicolas2
  • Alarcan, Hugo3
  • Barreau, Melody4
  • Becquemont, Laurent5
  • Quaranta, Sylvie6
  • Boyer, Jean-Christophe7
  • Loriot, Marie-Anne8
  • 1 Inserm U1248, laboratoire de biochimie et biologie moléculaire, université de Tours, CHU de tours, 2, boulevard Tonnellé, 37044 Tours cedex, France. Electronic address: chantal.barin-leguel[email protected] , (France)
  • 2 Inserm U1248, service de pharmacologie et toxicologie, université de Limoges, CHU de Limoges, 87042 Limoges, France. , (France)
  • 3 Inserm U1248, laboratoire de biochimie et biologie moléculaire, université de Tours, CHU de tours, 2, boulevard Tonnellé, 37044 Tours cedex, France. , (France)
  • 4 Inserm U1107, Service de pharmacologie, université d'Auvergne, CHU de Clermont-Ferrand, 63001 Clermont-Ferrand, France. , (France)
  • 5 CESP/Inserm U1018, Centre de recherche clinique, hôpital Bicêtre, université Paris Sud, 94275 Le Kremlin-Bicêtre, France. , (France)
  • 6 Laboratoire de pharmacocinétique et toxicologie, CHU Timone, 13005 Marseille, France. , (France)
  • 7 Laboratoire de biochimie et biologie moléculaire, CHU Carémeau, 30000 Nîmes, France. , (France)
  • 8 Inserm U1144, service de biochimie, hôpital européen Georges-Pompidou, université Paris Descartes, 75015 Paris, France. , (France)
Type
Published Article
Journal
Thérapie
Publisher
Elsevier
Publication Date
Jan 01, 2020
Volume
75
Issue
5
Pages
459–470
Identifiers
DOI: 10.1016/j.therap.2019.09.006
PMID: 31767126
Source
Medline
Keywords
Language
French
License
Unknown

Abstract

Pharmacogenetics, which concepts are known for a long time, is entering a new period at least as far as its practical applications for patients are concerned. In recent years there have been more and more initiatives to promote widespread dissemination, and health authorities are increasingly incorporating these concepts into drug labels. In France, the national network of pharmacogenetics (RNPGx) works to promote these activities, both with health actors (biologists, clinicians) and health authorities. This article reviews the current situation in France and the milestones of the year 2018. It highlights recent advances in this field, in terms of currently recommended analyses, sharing of information or technological developments, and the prospects for future developments in the near future from targeted pharmacogenetics to eventually preemptive approaches. Copyright © 2019 Société française de pharmacologie et de thérapeutique. Published by Elsevier Masson SAS. All rights reserved.

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