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Pharmacogenetics in heart failure: genomic markers of endothelial and neurohumoral function.

Authors
  • McNamara, Dennis M
Type
Published Article
Journal
Congestive heart failure (Greenwich, Conn.)
Publication Date
Jan 01, 2004
Volume
10
Issue
6
Pages
302–308
Identifiers
PMID: 15591845
Source
Medline
License
Unknown

Abstract

There is a high potential for pharmacogenetic interaction in the management of many diseases including heart failure. Although genetic tailoring of therapy is not yet a common medical practice, it is foreseeable that some forms of genetic targeting will become standard care by the end of the current decade. This review will summary how genetic variation in two genes involved in both endothelial function and heart failure pathogenesis, angiotensin-converting enzyme and endothelial nitric oxide synthase, influence both heart failure outcomes and the effects of standard therapies.

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