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Pharmacodynamics of vecuronium, atracurium, tubocurarine and their combinations in the rat in vivo.

Authors
  • Booij, L H
  • van Egmond, J
  • van de Pol, F
  • Crul, J F
Type
Published Article
Journal
European journal of anaesthesiology
Publication Date
Sep 01, 1985
Volume
2
Issue
3
Pages
279–284
Identifiers
PMID: 2866094
Source
Medline
License
Unknown

Abstract

In the in vivo rat sciatic nerve tibialis muscle preparation the potency and pharmacodynamics of vecuronium, atracurium, pancuronium, tubocurarine and their combinations were studied. Considering the potency only, there was no beneficial difference between the pure compounds and their combinations. As both vecuronium and atracurium are almost free from side-effects individually, a combination of the two relaxants brings no advantage.

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