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Pharmacodynamics OF TNF α inhibitors for the treatment of psoriasis.

Authors
  • Campanati, Anna1
  • Paolinelli, Matteo1
  • Diotallevi, Frederico1
  • Martina, Emanuela1
  • Molinelli, Elisa1
  • Offidani, Annamaria1
  • 1 Dermatological Clinic, Department of Clinical and Molecular Sciences, Polytechnic Marche University, Ancona, Italy. , (Italy)
Type
Published Article
Journal
Expert Opinion on Drug Metabolism & Toxicology
Publisher
Informa UK (Taylor & Francis)
Publication Date
Oct 29, 2019
Pages
1–13
Identifiers
DOI: 10.1080/17425255.2019.1681969
PMID: 31623470
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Introduction: The treatment of psoriasis with conventional topical therapies and disease-modifying anti-rheumatic drugs (DMARDs) is often linked to unsatisfactory outcomes and the risk of serious adverse events. Over the last decades, research advances in understanding the role of tumor necrosis factor alpha (TNF α) and other cytokines in the pathogenesis of psoriasis have driven the introduction of biologic agents targeting specific immune mediators in everyday clinical practice. TNF α inhibitors are a consolidated treatment option for patients with moderate-to-severe disease with remarkable efficacy and a reassuring safety profile.Areas covered: The PubMed database was searched using combinations of the following keywords: psoriasis, TNF α inhibitors, biologic therapy, pharmacodynamics, adalimumab, etanercept, infliximab, certolizumab pegol, golimumab, adverse effects. The aim of this review is to describe the pharmacodynamic profile of anti-TNF α inhibitors, currently approved by the European Medicines Agency (EMA) for the treatment of psoriasis, focusing on related clinical implications, also in comparison to the new generation biological therapies targeting the interleukin 23/interleukin 17 axis.Expert opinion: Pharmacodynamics of TNF α inhibitors should be fully considered in planning patient's therapy strategies, especially in case of secondary failures, poor adherence to treatment, instable psoriasis, high risk of infection, pregnant or lactating women, metabolic comorbidities, coexistence of other immune-mediated inflammatory diseases.

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