Affordable Access

Pharmacodynamic effects of amoxicillin versus cefotaxime against penicillin-susceptible and penicillin-resistant pneumococcal strains: a phase I study.

Authors
  • Aguilar, L
  • Rosendo, J
  • Balcabao, I P
  • Martín, M
  • Giménez, M J
  • Frías, J
  • Prieto, J
Type
Published Article
Journal
Antimicrobial agents and chemotherapy
Publication Date
Jun 01, 1997
Volume
41
Issue
6
Pages
1389–1391
Identifiers
PMID: 9174206
Source
Medline
License
Unknown

Abstract

Serum bactericidal activity against a penicillin-susceptible strain and a penicillin-resistant strain of Streptococcus pneumoniae (amoxicillin and cefotaxime MICs, 0.001 and 1 microg/ml, respectively, and MBCs, 0.01 and 2 microg/ml, respectively) was measured in 12 healthy volunteers who each received an oral 875-mg dose of amoxicillin and an intramuscular 1-g dose of cefotaxime in a crossover fashion. The areas under the bactericidal activity-time curves for the two strains were found to be similar for both antibiotics despite the significantly higher (P < 0.002) AUC/MIC and peak level/MIC values for cefotaxime.

Report this publication

Statistics

Seen <100 times