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Phagocytosis and related phenomena in polymorphonuclear leukocytes from cow's milk.

Authors
  • Kent, G M
  • Newbould, F H
Type
Published Article
Journal
Canadian journal of comparative medicine : Revue canadienne de médecine comparée
Publication Date
Jul 01, 1969
Volume
33
Issue
3
Pages
214–219
Identifiers
PMID: 4242772
Source
Medline
License
Unknown

Abstract

There were fewer efficient phagocytes among leukocytes collected from artificially irritated mammary glands than among the leukocytes from blood of the same animals. The milk polymorphonuclear (PMN) leukocytes adhered poorly to a column of siliconised glass beads when compared with the blood cells. However, investigations of the O(2) uptake and CO(2) production of the milk PMN leukocytes revealed that these cells appeared to utilize metabolic pathways similar to those used by human and guinea pig PMN leukocytes during phagocytosis. These pathways are associated with degranulation and the production of H(2)O(2) following particle ingestion. It is therefore suggested that the milk PMN leukocytes appear not to have lost the ability to produce this bactericidal substance.

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