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Phagocytosis of polystyrene latex beads by rat brain microglia cell cultures is increased by treatment with gangliosides.

Authors
Type
Published Article
Journal
Developmental Neuroscience
0378-5866
Publisher
S. Karger AG
Publication Date
Volume
10
Issue
4
Pages
270–276
Identifiers
PMID: 3224565
Source
Medline

Abstract

Cultures of microglial cells were prepared from primary rat brain cultures of astrocytes. Microglia appeared under two main forms: ameboid and ramified. Only the former were capable of ingesting opsonized latex particles of 1 and 6 micron; while the latter, which appeared later in culture, were not capable of phagocytosis. When gangliosides (10(-6) M), which are known for their neuronotrophic capacity in vitro, were added to the growth medium (for 20 min) they stimulated the phagocytosis of ameboid microglia 2-fold.

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