Affordable Access

Phagocytosis of outer segments by cultured rat pigment epithelium. Reduction by cyclic AMP and phosphodiesterase inhibitors.

Authors
  • Edwards, R B
  • Bakshian, S
Type
Published Article
Journal
Investigative Ophthalmology & Visual Science
Publisher
Association for Research in Vision and Ophthalmology (ARVO)
Publication Date
Oct 01, 1980
Volume
19
Issue
10
Pages
1184–1188
Identifiers
PMID: 6158495
Source
Medline
License
Unknown

Abstract

Phagocytosis of isolated outer segments by cultured rat pigment epithelium was decreased by cyclic 3',5'adenosine monophosphate (cyclic AMP), dibutyryl cyclic AMP, and three phosphodiesterase inhibitors (isobutylmethylxanthine, papaverine, and SQ 65442). Cyclic GMP and its dibutyryl derivative had little effect on phagocytosis. Phagocytosis was moderately reduced by several other purine nucleotides and nucleosides and substantially reduced by adenine.

Report this publication

Statistics

Seen <100 times