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PHA dose dependent defect in lymphocyte stimulation and E-rosette-forming cells in untreated Hodgkin's disease.

Authors
  • Land, J M
  • Litwin, J
  • Bigel, P
  • Oberling, F
  • Mayer, S
Type
Published Article
Journal
Acta haematologica Polonica
Publication Date
Jan 01, 1977
Volume
8
Issue
2
Pages
131–134
Identifiers
PMID: 329629
Source
Medline
License
Unknown

Abstract

14 untreated patients with Hodgkin's disease were tested for lymphocte reactivity in vitro to optimal and suboptimal doses of PHA. A PHA dose-dependent defect in lymphocyte stimulation was demonstrated in patients when compared with a group of normal individuals. No correlation between the in vitro defect and decreased absolute number of E-rosette-forming cells (T-lymphocytes) in peripheral blood was found.

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