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pH and Glucose Dual-Responsive Injectable Hydrogels with Insulin and Fibroblasts as Bioactive Dressings for Diabetic Wound Healing.

Authors
  • Zhao, Lingling1, 2
  • Niu, Lijing1
  • Liang, Hongze1
  • Tan, Hui3
  • Liu, Chaozong2
  • Zhu, Feiyan4
  • 1 Faculty of Materials Science and Chemical Engineering, Ningbo University , Ningbo 315211, China. , (China)
  • 2 Division of Surgery and Interventional Science, University College London , London HA7 4LP, U.K.
  • 3 Shenzhen Key Laboratory of Neurosurgery, Shenzhen Second People's Hospital , Shenzhen 518035, China. , (China)
  • 4 Shenzhen Key Laboratory of Tissue Engineering, Shenzhen Second People's Hospital , Shenzhen 518035, China. , (China)
Type
Published Article
Journal
ACS Applied Materials & Interfaces
Publisher
American Chemical Society
Publication Date
Nov 01, 2017
Volume
9
Issue
43
Pages
37563–37574
Identifiers
DOI: 10.1021/acsami.7b09395
PMID: 28994281
Source
Medline
Keywords
License
Unknown

Abstract

pH and glucose dual-responsive injectable hydrogels were prepared through the cross-linking of Schiff's base and phenylboronate ester using phenylboronic-modified chitosan, poly(vinyl alcohol) and benzaldehyde-capped poly(ethylene glycol). Protein drugs and live cells could be incorporated into the hydrogels during the in situ cross-linking, displaying sustained and pH/glucose-triggered drug release from the hydrogels and cell viability and proliferation in the three-dimensional hydrogel matrix as well. Hence, the hydrogels with insulin and fibroblasts were considered as bioactive dressings for diabetic wound healing. A streptozotocin-induced diabetic rat model was used to evaluate the efficacy of hydrogel dressings in wound repair. The results revealed that the incorporation of insulin and L929 in the hydrogels could promote neovascularization and collagen deposition and enhance the wound-healing process of diabetic wounds. Thus, the drug- and cell-loaded hydrogels have promising potential in wound healing as a medicated system for various therapeutic proteins and live cells.

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