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PFRED: A computational platform for siRNA and antisense oligonucleotides design [preprint]

Authors
  • Sciabola, Simone
  • Xi, Hualin
  • Cruz, Dario
  • Cao, Qing
  • Lawrence, Christine
  • Zhang, Tianhong
  • Rotstein, Sergio
  • Hughes, Jason D.
  • Caffrey, Daniel R.
  • Stanton, Robert
Publication Date
Aug 25, 2020
Source
[email protected]
Keywords
License
Green
External links

Abstract

PFRED a software application for the design, analysis, and visualization of antisense oligonucleotides and siRNA is described. The software provides an intuitive user-interface for scientists to design a library of siRNA or antisense oligonucleotides that target a specific gene of interest. Moreover, the tool facilitates the incorporation of various design criteria that have been shown to be important for stability and potency. PFRED has been made available as an open-source project so the code can be easily modified to address the future needs of the oligonucleotide research community. A compiled version is available for downloading at https://github.com/pfred/pfred-gui/releases as a java Jar file. The source code and the links for downloading the precompiled version can be found at https://github.com/pfred.

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