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Peyer’s Patches in the Terminal Ileum in Ulcerative Colitis: Magnifying Endoscopic Findings

Authors
  • Ishii, Hiroyuki1, 2
  • Isomoto, Hajime2
  • Shikuwa, Saburo2
  • Hayashi, Tomayoshi3
  • Inoue, Naoki2
  • Yamaguchi, Naoyuki2
  • Ohnita, Ken2
  • Nanashima, Atsushi4
  • Ito, Masahiro5
  • Nakao, Kazuhiko2
  • Kohno, Shigeru1
  • 1 Second Department of Internal Medicine, Nagasaki University Hospital, 1-7-1 Sakamoto, Nagasaki 852-8501, Japan
  • 2 Department of Gastroenterology and Hepatology, Nagasaki University Hospital, 1-7-1 Sakamoto, Nagasaki 852-8501, Japan
  • 3 Department of Pathology, Nagasaki University Hospital, 1-7-1 Sakamoto, Nagasaki 852-8501, Japan
  • 4 First Department of Surgery, Nagasaki University Hospital, 1-7-1 Sakamoto, Nagasaki 852-8501, Japan
  • 5 Department of Pathology, National Nagasaki Medical Center, 2-1001-1 Kubara, Omura 856-8562, Japan
Type
Published Article
Journal
Journal of Clinical Biochemistry and Nutrition
Publisher
the Society for Free Radical Research Japan
Publication Date
Feb 27, 2010
Volume
46
Issue
2
Pages
111–118
Identifiers
DOI: 10.3164/jcbn.09-77
PMID: 20216943
PMCID: PMC2831089
Source
PubMed Central
Keywords
License
Green

Abstract

Peyer’s patches (PPs), a major component of the gut-associated lymphoid tissue, serve as important antigen entry sites in mucosal immunity. PPs may play a role in the extension of ulcerative colitis (UC) into the terminal ileum. We sought to clarify the magnified endoscopic findings of the PPs in the terminal ileum of UC patients. Eighteen UC patients underwent magnifying chromoendoscopy before initial treatment to evaluate the follicle-associated epithelium (FAE) on the PPs domes and the surrounding villi. In 8 UC patients, as in healthy controls, the PPs’ domes were slightly elevated, covered with the regular FAE lining, and surrounded by dense and bulky villi; however, in 10 UC patients, the PPs’ domes were irregular, and the surrounding villi were sparse and atrophic. These abnormal findings within the PPs were associated with minimal mucosal lesions but not with backwash ileitis; both electron microscopy and magnifying endoscopy confirmed that these lesions were reversible following remission with prednisolone-mesalazine therapy. Similar to Crohn’s disease patients, UC patients commonly had abnormalities in the FAE on PPs’ domes and the surrounding villi on magnifying endoscopy.

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