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Pex19p dampens the p19ARF-p53-p21WAF1 tumor suppressor pathway.

Authors
  • Sugihara, T
  • Kaul, S C
  • Kato, J
  • Reddel, R R
  • Nomura, H
  • Wadhwa, R
Type
Published Article
Journal
The Journal of biological chemistry
Publication Date
Jun 01, 2001
Volume
276
Issue
22
Pages
18649–18652
Identifiers
PMID: 11259404
Source
Medline
License
Unknown

Abstract

We isolated a 33-kDa protein, Pex19p/HK33/HsPXF, as a p19ARF-binding protein in a yeast two-hybrid screen. We demonstrate here that Pex19p interacts with p19ARF in the cell cytoplasm and excludes p19ARF from the nucleus, leading to a concurrent inactivation of p53 function. Down-regulation of Pex19p by its antisense expression resulted in increased levels of p19ARF, increased p53 function, and a p53/p21WAF1-mediated senescence-like cell cycle arrest. The data demonstrated a novel mechanism of down-regulation of the p19ARF-p53 pathway.

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