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Pesticides and metals induced Parkinson's disease: involvement of free radicals and oxidative stress.

Authors
  • Singh, C
  • Ahmad, I
  • Kumar, A
Type
Published Article
Journal
Cellular and molecular biology (Noisy-le-Grand, France)
Publication Date
Jan 01, 2007
Volume
53
Issue
5
Pages
19–28
Identifiers
PMID: 17543230
Source
Medline
License
Unknown

Abstract

Environmental factors play a critical role in the etiology of Parkinson's disease in genetically susceptible aged individuals. Epidemiological findings have suggested the role of pesticides and metals in the onset and progression of Parkinson's disease. Environmental chemicals such as pesticides and metals induced PD animal models are established and evidences obtained from biochemical; molecular and behavioral studies indicated significant contribution of oxidative stress in PD. In this article, an update on the role of free radicals and antioxidants in the onset and progression of pesticides and metals induced PD has been discussed.

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