Affordable Access

Pesticide use and risk of non-Hodgkin lymphoid malignancies in agricultural cohorts from France, Norway and the USA: a pooled analysis from the AGRICOH consortium

Authors
  • Leon, Maria
  • Schinasi, Leah
  • Lebailly, Pierre
  • Beane Freeman, Laura
  • Nordby, Karl-Christian
  • Ferro, Gilles
  • Monnereau, Alain
  • Brouwer, Maartje
  • Tual, Séverine
  • Baldi, Isabelle
  • Kjaerheim, Kristina
  • Hofmann, Jonathan
  • Kristensen, Petter
  • Koutros, Stella
  • Straif, Kurt
  • Kromhout, Hans
  • Schüz, Joachim
Publication Date
Mar 18, 2019
Source
HAL-INRIA
Keywords
Language
English
License
Unknown
External links

Abstract

BACKGROUND:Pesticides are commonly used in agriculture, and previous studies endorsed the need to further investigate the possible association between their use and risk of lymphoid malignancies in agricultural workers.METHODS:We investigated the relationship of ever use of 14 selected pesticide chemical groups and 33 individual active chemical ingredients with non-Hodgkin lymphoid malignancies (NHL) overall or major subtypes, in a pooled analysis of three large agricultural worker cohorts. Pesticide use was derived from self-reported history of crops cultivated combined with crop-exposure matrices (France and Norway) or self-reported lifetime use of active ingredients (USA). Cox regression models were used to estimate cohort-specific hazard ratios (HRs) and 95% confidence intervals (CIs), which were combined using random effects meta-analysis to calculate meta-HRs.RESULTS:During follow-up, 2430 NHL cases were diagnosed in 316 270 farmers accruing 3 574 815 person-years under risk. Most meta-HRs suggested no association. Moderately elevated meta-HRs were seen for: NHL and ever use of terbufos (meta-HR = 1.18, 95% CI: 1.00-1.39); chronic lymphocytic leukaemia/small lymphocytic lymphoma and deltamethrin (1.48, 1.06-2.07); and diffuse large B-cell lymphoma and glyphosate (1.36, 1.00-1.85); as well as inverse associations of NHL with the broader groups of organochlorine insecticides (0.86, 0.74-0.99) and phenoxy herbicides (0.81, 0.67-0.98), but not with active ingredients within these groups, after adjusting for exposure to other pesticides.CONCLUSIONS:Associations of pesticides with NHL appear to be subtype- and chemical-specific. Non-differential exposure misclassification was an important limitation, showing the need for refinement of exposure estimates and exposure-response analyses.

Report this publication

Statistics

Seen <100 times