Affordable Access

Perturbations in carbohydrate metabolism during cypermethrin toxicity in fish, Tilapia mossambica.

Authors
  • Reddy, A T
  • Yellamma, K
Type
Published Article
Journal
Biochemistry international
Publication Date
Mar 01, 1991
Volume
23
Issue
4
Pages
633–638
Identifiers
PMID: 1872878
Source
Medline
License
Unknown

Abstract

Sublethal concentrations (0.04 ppm) of cypermethrin induced significant metabolic changes in brain, liver and gill tissues of fish, T. mossambica. While cypermethrin caused depletion in glycogen and pyruvate levels lactate content was elevated in all the tissues. While phosphorylase 'a' and aldolase activity increased, phosphorylase 'b' activity registered a decrease in the present study. A decrease in lactate dehydrogenase activity with increase in lactate levels suggests reduced mobilization of pyruvate into citric acid cycle. Glucose-6-phosphate dehydrogenase activity was also elevated indicating enhanced oxidation through HMP pathway during cypermethrin toxicity. Inhibition of succinate, malate and isocitrate dehydrogenases and cytochrome c oxidase activity indicates impaired oxidation of carbohydrates through citric acid cycle.

Report this publication

Statistics

Seen <100 times