Perspectives in Medicinal Chemistry: DNA Methylation and Demethylation Mechanisms as Therapeutic Targets?

A majority of cancers display alterations in epigenetic mechanisms, such as aberrant DNA methylation at CpG islands (CGIs). This local hypermethy-lation of CGIs is associated with gene silencing leading to loss of tumor sup-pressor gene (TSG) functions that are critical for the control of tumor devel-opment. Concomitantly, global genomic hypomethylation contributes to ge-nomic instability and oncogene activation. These aberrant methylation pat-terns are cancer type-specific DNA Methylation and Demethylation Mechanisms as Therapeutic Targets? (PDF Download Available). Available from: https://www.researchgate.net/publication/282874866_DNA_Methylation_and_Demethylation_Mechanisms_as_Therapeutic_Targets [accessed May 24, 2017]...