Affordable Access

deepdyve-link
Publisher Website

Personality disorders in offspring of mothers with mood disorders: results from a longitudinal family study.

Authors
  • Cullen, Kathryn R1
  • Eberly, Lynn E2
  • Heller, Monika D3
  • Schlesinger, Amanda3
  • Gold, Phillip W4
  • Martinez, Pedro E4
  • Klimes-Dougan, Bonnie5
  • 1 Department of Psychiatry, University of Minnesota Medical School, Minneapolis, MN, USA. Electronic address: [email protected]
  • 2 Division of Biostatistics, School of Public Health, University of Minnesota, Minneapolis, MN, USA.
  • 3 Department of Psychiatry, University of Minnesota Medical School, Minneapolis, MN, USA.
  • 4 National Institutes of Mental Health, Bethesda, MD, USA.
  • 5 Department of Psychology, University of Minnesota, Minneapolis, MN USA.
Type
Published Article
Journal
Psychiatry research
Publication Date
Aug 30, 2014
Volume
218
Issue
3
Pages
303–310
Identifiers
DOI: 10.1016/j.psychres.2014.04.044
PMID: 24844978
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Offspring of mothers with mood disorders are known to be at risk for a range of adverse outcomes, but the prevalence of personality disorders (PDs) in this group is unknown. The goal of this study was to assess risk of PD diagnoses and symptoms in offspring of mothers with and without mood disorders, and to explore contributing factors to this risk. This longitudinal study assessed PDs and symptoms of PDs in offspring of mothers with bipolar disorder (O-BD), major depression (O-MDD), and no psychiatric diagnosis (O-WELL) in mid-adolescence and in early adulthood. O-BD were more likely to develop a Cluster B PD than O-MDD or O-WELL in adolescence, and more likely to develop a Cluster B PD then O-WELL in early adulthood. Dimensional analyses revealed that O-BD had elevated symptoms in PDs across all PD clusters at mid-adolescence and young adulthood. O-MDD showed elevated symptoms of antisocial PD at both time points, and of obsessive-compulsive PD at young adulthood. Offspring of mothers with mood disorders, especially O-BD, are at increased risk for PD diagnoses and symptoms in mid-adolescence and early adulthood. Contributing factors to risk of PD symptoms in at-risk offspring are discussed. Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.

Report this publication

Statistics

Seen <100 times