52 elderly women and 36 matched by age and education men with initiatory stages of chronic brain ischemia (CBI) have been studied using comparative analysis of personality characteristics. Women with CBI had higher level of psychosocial stress than men. The results demonstrate the predomination of extrapunitive frustration reactions among women. Intropunitive ones prevailed in men. Women-patients had higher levels of excitement, stress and anxiety than men that surpassed women by the indicators of emotional security. The received data may be important for individualization of therapeutic intervention.