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[Personalised COPD care: Where are we going?]

Authors
  • Roche, N1
  • Martin, C2
  • Burgel, P-R2
  • 1 EA2511, service de pneumologie, université Paris Descartes, hôpital Cochin, hôpitaux universitaires Paris Centre, AP-HP 5, 27, rue du Faubourg-Saint-Jacques, 75014 Paris, France. Electronic address: [email protected] , (France)
  • 2 EA2511, service de pneumologie, université Paris Descartes, hôpital Cochin, hôpitaux universitaires Paris Centre, AP-HP 5, 27, rue du Faubourg-Saint-Jacques, 75014 Paris, France. , (France)
Type
Published Article
Journal
Revue de Pneumologie Clinique
Publisher
Elsevier
Publication Date
Oct 01, 2018
Volume
74
Issue
5
Pages
315–326
Identifiers
DOI: 10.1016/j.pneumo.2018.09.003
PMID: 30316649
Source
Medline
Keywords
Language
French
License
Unknown

Abstract

The concept of personalised medicine is recent but the underlying notions are not new: knowing how to adapt care to patients' characteristics is one of the components of the "art of medicine". The advances of science allow to refine considerably the applications of the concept in many fields of medicine including COPD: research has identified phenotypes, endotypes and treatable traits. Personalisation can be applied to all components of care. For instance, the decision to perform screening spirometry relies not only on risk factors (age, smoking, other exposures) but also on symptoms. Assessment of comorbidities often associated with COPD is based on risk factors and their combinations, variable between individuals. Rehabilitation and its components are in essence highly individualised, which a major condition for their success. Last but not least, personalisation of pharmacological therapy, which has long been rather poor, could not benefit from biomarkers of interest (predictive of response), such as blood eosinophil count. Practical strategies using these still need to be established, and new biomarkers may usefully enrich the collection! Copyright © 2018 Elsevier Masson SAS. All rights reserved.

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