Affordable Access

Persistently high plasma morphine-6-glucuronide levels despite decreased hourly patient-controlled analgesia morphine use after single-dose diclofenac: potential for opioid-related toxicity.

Authors
Type
Published Article
Journal
Anesthesia & Analgesia
0003-2999
Publisher
Ovid Technologies (Wolters Kluwer) - Anesthesia & Analgesia
Publication Date
Volume
88
Issue
5
Pages
1137–1142
Identifiers
PMID: 10320184
Source
Medline

Abstract

Plasma concentrations of morphine, morphine-6-glucuronide, and diclofenac were measured postoperatively after a single dose of rectal diclofenac 100 mg was added to morphine patient-controlled analgesia. Peak analgesia occurred 309 min and respiratory depression 197 min after diclofenac administration. Morphine consumption had decreased by 20%, but concentrations of the active metabolite morphine-6-glucuronide were unchanged. Vigilance is recommended in patients receiving patient-controlled analgesia opioids and nonsteroidal antiinflammatory drugs.

There are no comments yet on this publication. Be the first to share your thoughts.

Statistics

Seen <100 times
0 Comments