Affordable Access

deepdyve-link
Publisher Website

The role of GABA in human motor learning.

Authors
  • Stagg, Charlotte J1
  • Bachtiar, Velicia
  • Johansen-Berg, Heidi
  • 1 Oxford Centre for Functional Magnetic Resonance Imaging of the Brain (FMRIB), Department of Clinical Neurosciences, University of Oxford, Oxford OX3 9DU, UK. [email protected]
Type
Published Article
Journal
Current biology : CB
Publication Date
Mar 22, 2011
Volume
21
Issue
6
Pages
480–484
Identifiers
DOI: 10.1016/j.cub.2011.01.069
PMID: 21376596
Source
Medline
License
Unknown

Abstract

GABA modification plays an important role in motor cortical plasticity. We therefore hypothesized that interindividual variation in the responsiveness of the GABA system to modification influences learning capacity in healthy adults. We assessed GABA responsiveness by transcranial direct current stimulation (tDCS), an intervention known to decrease GABA. The magnitude of M1 GABA decrease induced by anodal tDCS correlated positively with both the degree of motor learning and the degree of fMRI signal change within the left M1 during learning. This study therefore suggests that the responsiveness of the GABAergic system to modification may be relevant to short-term motor learning behavior and learning-related brain activity.

Report this publication

Statistics

Seen <100 times