Affordable Access

Persistent multifocal conduction block in vasculitic neuropathy with IgM anti-gangliosides.

Authors
  • Notturno, Francesca
  • Caporale, Christina M
  • Di Muzio, Antonio
  • Uncini, Antonino
Type
Published Article
Journal
Muscle & nerve
Publication Date
Oct 01, 2007
Volume
36
Issue
4
Pages
547–552
Identifiers
PMID: 17405140
Source
Medline
License
Unknown

Abstract

A 30-year-old man with essential cryoglobulinemia presented with an axonal neuropathy and was found to have vasculitis at nerve biopsy. After 44 months, in accord with clinical deterioration, motor conduction studies showed excessive temporal dispersion multifocally, with partial conduction block persisting for 3 years. Antibody testing showed the presence of IgM anti-GM1, anti-GD1a, and anti-GM2 antibodies. Transitory conduction block has been reported occasionally in patients with vasculitis. The persistent multifocal conduction abnormalities found in this patient were more likely due to a superimposed immunomediated demyelination rather than to chronic nerve ischemia secondary to vasculitis.

Report this publication

Statistics

Seen <100 times