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[Persistent influenza virus infection in a MDCK cell culture].

Authors
Type
Published Article
Journal
Voprosy virusologii
Publication Date
Volume
29
Issue
5
Pages
536–539
Identifiers
PMID: 6516326
Source
Medline
License
Unknown

Abstract

A model of persistent influenza infection (PII) induced by influenza A/Victoria/35/72 (H3N2) virus in MDCK cell culture has been constructed. The model was observed for 165 days. It was characterized by the lack of visible signs of virus reproduction, a low number of antigen-containing cells (0.02-0.05%), irregular virus isolation (at 20, 28, 32, 44, 52, 62, 92, 135, 148, 158 days after primary inoculation) which was possible only with special methods. Interferon and DIP were found not to be the factors responsible for maintenance of PII in MDCK culture.

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