Affordable Access

Persistence of T-cell clones in psoriatic lesions.

Authors
  • Chang, J C
  • Smith, L R
  • Froning, K J
  • Kurland, H H
  • Schwabe, B J
  • Blumeyer, K K
  • Karasek, M A
  • Wilkinson, D I
  • Farber, E M
  • Carlo, D J
  • Brostoff, S W
Type
Published Article
Journal
Archives of Dermatology
Publisher
American Medical Association
Publication Date
Jun 01, 1997
Volume
133
Issue
6
Pages
703–708
Identifiers
PMID: 9197823
Source
Medline
License
Unknown

Abstract

The clonality, which was found in the V beta messages of the sorted CD8+ T cells, accurately reflects the dominance of these clones in the infiltrating T cells. Moreover, the persistence in the same patient of the same clone for as long as 15 months and the overrepresentation of V beta 3 and/or V beta 13.1 in lesional CD8+ T cells in the new patients examined support the pathogenic role of T cells bearing these V betas.

Report this publication

Statistics

Seen <100 times