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Persistence of T-cell clones in psoriatic lesions.

Authors
Type
Published Article
Journal
Archives of Dermatology
0003-987X
Publisher
American Medical Association
Publication Date
Volume
133
Issue
6
Pages
703–708
Identifiers
PMID: 9197823
Source
Medline

Abstract

The clonality, which was found in the V beta messages of the sorted CD8+ T cells, accurately reflects the dominance of these clones in the infiltrating T cells. Moreover, the persistence in the same patient of the same clone for as long as 15 months and the overrepresentation of V beta 3 and/or V beta 13.1 in lesional CD8+ T cells in the new patients examined support the pathogenic role of T cells bearing these V betas.

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