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Persistence of a large population of exhausted monoclonal B cells in mixed cryoglobuliemia after the eradication of hepatitis C virus infection.

Authors
  • Visentini, Marcella
  • Conti, Valentina
  • Cagliuso, Maria
  • Siciliano, Giulia
  • Scagnolari, Carolina
  • Casato, Milvia
  • Fiorilli, Massimo
Type
Published Article
Journal
Journal of Clinical Immunology
Publisher
Springer-Verlag
Publication Date
Aug 01, 2012
Volume
32
Issue
4
Pages
729–735
Identifiers
DOI: 10.1007/s10875-012-9677-0
PMID: 22382878
Source
Medline
License
Unknown

Abstract

Clonal expansion of CD21(low) V(H)1-69(+) B cells may depend on continual stimulation by HCV, whereas their MZ-like counterparts may persist for years after the eradication of infection. Prolonged survival of exhausted MZ-like B cells after withdrawal of the initial inciting stimulus may contribute to the accumulation of autoreactive B cells in immunological disorders.

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