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Peroxisome proliferator activated receptor gamma in colonic epithelial cells protects against experimental inflammatory bowel disease.

Authors
  • Adachi, M
  • Kurotani, R
  • Morimura, K
  • Shah, Y
  • Sanford, M
  • Madison, B B
  • Gumucio, D L
  • Marin, H E
  • Peters, J M
  • Young, H A
  • Gonzalez, F J
Type
Published Article
Journal
Gut
Publication Date
Aug 01, 2006
Volume
55
Issue
8
Pages
1104–1113
Identifiers
PMID: 16547072
Source
Medline
License
Unknown

Abstract

These studies reveal that PPARgamma expressed in the colonic epithelium has an endogenous role in protection against DSS induced colitis and that rosiglitazone may act through a PPARgamma independent pathway to suppress inflammation.

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