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Peroxisome proliferator-activated receptor-alpha and -gamma mRNA levels are reduced in chronic hepatitis C with steatosis and genotype 3 infection.

Authors
  • de Gottardi, A
  • Pazienza, V
  • Pugnale, P
  • Bruttin, F
  • Rubbia-Brandt, L
  • Juge-Aubry, C E
  • Meier, C A
  • Hadengue, A
  • Negro, F
Type
Published Article
Journal
Alimentary pharmacology & therapeutics
Publication Date
Jan 01, 2006
Volume
23
Issue
1
Pages
107–114
Identifiers
PMID: 16393287
Source
Medline
License
Unknown

Abstract

The presence of steatosis and hepatitis C virus genotype 3 are both associated with a significant down-regulation of PPARs. These receptors, and also additional factors, seem to play a role in the pathogenesis of hepatitis C virus-associated steatosis.

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