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The permissive effects of glucose on receptor-operated potentiation of insulin secretion from mouse islets: a role for ERK1/2 activation and cytoskeletal remodelling.

Authors
  • Bowe, J E
  • Chander, A
  • Liu, B
  • Persaud, S J
  • Jones, P M
Type
Published Article
Journal
Diabetologia
Publisher
Springer-Verlag
Publication Date
Apr 01, 2013
Volume
56
Issue
4
Pages
783–791
Identifiers
DOI: 10.1007/s00125-012-2828-2
PMID: 23344729
Source
Medline
License
Unknown

Abstract

Glucose-induced ERK1/2 activation in beta cells mediates the permissive effects of stimulatory glucose concentrations on receptor-operated insulin secretagogues, at least in part through effects on actin depolymerisation and cytoskeletal remodelling.

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