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Permeability of PEGylated immunoarsonoliposomes through in vitro blood brain barrier-medulloblastoma co-culture models for brain tumor therapy.

Authors
  • Al-Shehri, Abdulghani
  • Favretto, Marco E
  • Ioannou, Panayiotis V
  • Romero, Ignacio A
  • Couraud, Pierre-Olivier
  • Weksler, Babette Barbash
  • Parker, Terry L
  • Kallinteri, Paraskevi
Type
Published Article
Journal
Pharmaceutical Research
Publisher
Springer-Verlag
Publication Date
Mar 01, 2015
Volume
32
Issue
3
Pages
1072–1083
Identifiers
DOI: 10.1007/s11095-014-1519-8
PMID: 25236341
Source
Medline
License
Unknown

Abstract

The three-dimensional models might be appropriate models to study the transport of various drugs and nanocarriers (liposomes and immunoarsonoliposomes) through the healthy and diseased BBB. The immunoarsonoliposomes can be potentially used as anticancer agents due to good tolerance of the in vitro BBB model to their toxic effect.

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