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Permanent Bilateral Carotid Filters for Stroke Prevention in Atrial Fibrillation

Authors
  • De Potter, Tom1
  • Yodfat, Ofer2
  • Shinar, Guy2
  • Neta, Avraham2
  • Reddy, Vivek Y.3
  • Neuzil, Petr4
  • Veltkamp, Roland5, 6, 7
  • Connolly, Stuart J.8
  • 1 Cardiovascular Center, OLV Hospital, Moorselbaan 164, Aalst, B-9300, Belgium , Aalst (Belgium)
  • 2 Javelin Medical Ltd., Yokne’am, Israel , Yokne’am (Israel)
  • 3 Icahn School of Medicine at Mount Sinai, New York, NY, USA , New York (United States)
  • 4 Homolka Hospital, Prague, Czech Republic , Prague (Czechia)
  • 5 Imperial College London, London, UK , London (United Kingdom)
  • 6 Alfried Krupp Krankenhaus, Essen, Germany , Essen (Germany)
  • 7 University Heidelberg, Heidelberg, Germany , Heidelberg (Germany)
  • 8 McMaster University, Hamilton, Ontario, Canada , Hamilton (Canada)
Type
Published Article
Journal
Current Cardiology Reports
Publisher
Springer-Verlag
Publication Date
Sep 10, 2020
Volume
22
Issue
11
Identifiers
DOI: 10.1007/s11886-020-01388-w
Source
Springer Nature
Keywords
License
Green

Abstract

Purpose of ReviewA novel permanent carotid filter device for percutaneous implantation was developed for the purpose of stroke prevention. In this review, we cover rationale, existing preclinical and clinical data, and potential future directions for research using such a device.Recent FindingsThe Vine™ filter was assessed for safety in sheep and in 2 observational human studies, the completed CAPTURE 1 (n = 25) and the ongoing CAPTURE 2 (planned n = 100). CAPTURE 1 has shown high procedural and long-term implant safety. A control group was not available for comparison.SummaryA mechanical filter for permanent stroke prevention can be implanted bilaterally in the common carotid artery safely and efficiently. A randomized trial is planned for 2021 (n = 3500, INTERCEPT) to demonstrate superiority of a filter + anticoagulation strategy over anticoagulation alone in patients at high risk for ischemic stroke.

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