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Peri-tumoral Metallic Implants Reduce the Efficacy of Irreversible Electroporation for the Ablation of Colorectal Liver Metastases.

Authors
  • Cornelis, Francois H1, 2
  • Cindrič, Helena3
  • Kos, Bor3
  • Fujimori, Masashi1
  • Petre, Elena N1
  • Miklavčič, Damijan3
  • Solomon, Stephen B1
  • Srimathveeravalli, Govindarajan4, 5
  • 1 Department of Radiology, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY, 10065, USA.
  • 2 Tenon Hospital, ISCD, Sorbonne Université, 4 Rue de la Chine, 75020, Paris, France. , (France)
  • 3 Faculty of Electrical Engineering, University of Ljubljana, Tržaška 25, 1000, Ljubljana, Slovenia. , (Slovenia)
  • 4 Department of Mechanical and Industrial Engineering, University of Massachusetts, Amherst, MA, 01003, USA. [email protected]
  • 5 Institute for Applied Life Sciences, University of Massachusetts, Amherst, MA, 01003, USA. [email protected]
Type
Published Article
Journal
CardioVascular and Interventional Radiology
Publisher
Springer-Verlag
Publication Date
Jan 01, 2020
Volume
43
Issue
1
Pages
84–93
Identifiers
DOI: 10.1007/s00270-019-02300-y
PMID: 31385006
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

To evaluate the effect of peri-tumoral metallic implants (MI) on the safety and efficacy of percutaneous irreversible electroporation (IRE) of colorectal liver metastasis (CRLM). In this retrospective study, 25 patients (12 women, 13 men; MI: 13, no MI: 12) were treated for 29 CRLM. Patient characteristics, tumor location and size, treatment parameters and the presence of MI were evaluated as determinants of local tumor progression (LTP) with the competing risks model (univariate and multivariate analyses). Patient-specific computer models were created to examine the effect of the MI on the electric field used to induce IRE, probability of cell kill and potential thermal effects. Patients had a median follow-up of 25 months, during which no IRE-related major complications were reported. Univariate analysis showed that tumor size (> 2 cm), probe spacing (> 20 mm) and the presence of MI (p < 0.05) were significant predictors of time to LTP, but only the latter was found to be an independent predictor on multivariate analysis (sub-hazard ratio = 6.5; [95% CI 1.99, 21.4]; p = 0.002). The absence of peri-tumoral MI was associated with higher progression-free survival at 12 months (92.3% [56.6, 98.9] vs 12.5% [2.1, 32.8]). Computer simulations indicated significant distortions and reduction in electric field strength near MI, which could have contributed to under-treatment of the tumor. Peri-tumoral MI increases the risk of treatment failure following IRE of CRLM.

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