Affordable Access

deepdyve-link
Publisher Website

Peritoneal mesothelioma in Sweden: A population-based study.

Authors
  • Cashin, Peter H1
  • Jansson Palmer, Gabriella2
  • Asplund, Dan3
  • Graf, Wilhelm1
  • Syk, Ingvar4
  • 1 Department of Surgical Sciences, Section of Surgery, Uppsala University, Uppsala, Sweden. , (Sweden)
  • 2 Department of Molecular Medicin and Surgery, Karolinska Institutet, Stockholm, Sweden. , (Sweden)
  • 3 Department of Surgery, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Sahlgrenska University - Hospital/Östra, Göteborg, Sweden. , (Sweden)
  • 4 Department of clinical science, Lund University, Skåne University Hospital, Malmö, Sweden. , (Sweden)
Type
Published Article
Journal
Cancer Medicine
Publisher
Wiley
Publication Date
Oct 01, 2019
Volume
8
Issue
14
Pages
6468–6475
Identifiers
DOI: 10.1002/cam4.2436
PMID: 31483564
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

The study aim was to report survival and morbidity of all patients in Sweden with peritoneal mesothelioma treated with cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) as well as investigate whether the survival has increased on a population level since this treatment was nationalized 2011. Study data were collected from the Swedish HIPEC registry and the Swedish National Cancer Registry. All patients with peritoneal mesothelioma scheduled for CRS/HIPEC treatment in Sweden January 2011 to March 2018 were retrieved from the Swedish HIPEC registry. Clinicopathological and survival data were collected. For population-level analysis, all patients with diffuse malignant peritoneal mesothelioma (DMPM) were identified from the Swedish National Cancer Registry and data were retrieved from two separate 5-year time periods: 1999-2003 and 2011-2015. Thirty-two patients were accepted for CRS/HIPEC. Four were open/close cases. Two-year survival rate was 84% or 59% when excluding borderline peritoneal mesotheliomas (n = 17). Median overall survival was not reached. Grade III-IV Clavien-Dindo events occurred in 22% with no mortality. From the national cancer registry, 102 DMPM cases were retrieved: 40 cases between 1999 and 2003, and 62 cases between 2011 and 2015 (corresponding to an increase from 0.9 to 1.24/million/year, P = .04). Six patients (10%) received CRS/HIPEC in the second period. Median OS increased between periods from 7 to 15 months and 5-year survival from 14% to 29% (P = .03). Peritoneal mesothelioma of both borderline and DMPM subtypes undergoing CRS/HIPEC have good long-term survival. The incidence of DMPM in Sweden has increased. Overall survival has increased alongside the introduction of CRS/HIPEC, which may be a contributing factor. © 2019 The Authors. Cancer Medicine published by John Wiley & Sons Ltd.

Report this publication

Statistics

Seen <100 times