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Peripheral insulin and brain structure in early Alzheimer disease.

Authors
  • Burns, J M
  • Donnelly, J E
  • Anderson, H S
  • Mayo, M S
  • Spencer-Gardner, L
  • Thomas, G
  • Cronk, B B
  • Haddad, Z
  • Klima, D
  • Hansen, D
  • Brooks, W M
Type
Published Article
Journal
Neurology
Publisher
Ovid Technologies (Wolters Kluwer) - American Academy of Neurology
Publication Date
Sep 11, 2007
Volume
69
Issue
11
Pages
1094–1104
Identifiers
PMID: 17846409
Source
Medline
License
Unknown

Abstract

Increased peripheral insulin is associated with reduced Alzheimer disease (AD)-related brain atrophy, cognitive dysfunction, and dementia severity, suggesting that insulin signaling may play a role in the pathophysiology of AD.

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