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Perioperative chemotherapy in locally advanced gastric cancer.

Authors
  • Batista, Thales Paulo
  • Santos, Candice Amorim de Araújo Lima
  • Almeida, Gustavo Fernandes Godoy
Type
Published Article
Journal
Arquivos de gastroenterologia
Publication Date
Jan 01, 2013
Volume
50
Issue
3
Pages
236–242
Identifiers
DOI: 10.1590/S0004-28032013000200042
PMID: 24322198
Source
Medline
License
Unknown

Abstract

Gastric cancer is one of the most common cancers and a main cause of cancer-related death worldwide, since the majority of patients suffering of this malignancy are usually faced with a poor prognosis due to diagnosis at later stages. In order to improve treatment outcomes, the association of surgery with chemo and/or radiotherapy (multimodal therapy) has become the standard treatment for locally advanced stages. However, despite several treatment options currently available for management of these tumors, perioperative chemotherapy has been mainly accepted for the comprehensive therapeutic strategy including an appropriated D2-gastrectomy. This manuscript presents a (nonsystematic) critical review about the use of perioperative chemotherapy, with a special focus on the drugs delivery.

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