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Periodic heart rate decelerations in premature infants.

Authors
  • Flower, Abigail A
  • Moorman, J Randall
  • Lake, Douglas E
  • Delos, John B
Type
Published Article
Journal
Experimental biology and medicine (Maywood, N.J.)
Publication Date
Apr 01, 2010
Volume
235
Issue
4
Pages
531–538
Identifiers
DOI: 10.1258/ebm.2010.009336
PMID: 20407086
Source
Medline
License
Unknown

Abstract

The pacemaking system of the heart is complex; a healthy heart constantly integrates and responds to extracardiac signals, resulting in highly complex heart rate patterns with a great deal of variability. In the laboratory and in some pathological or age-related states, however, dynamics can show reduced complexity that is more readily described and modeled. Reduced heart rate complexity has both clinical and dynamical significance - it may provide warning of impending illness or clues about the dynamics of the heart's pacemaking system. In this paper, we describe simple and interesting heart rate dynamics that we have observed in premature human infants - reversible transitions to large-amplitude periodic oscillations - and we show that the appearance and disappearance of these periodic oscillations can be described by a simple mathematical model, a Hopf bifurcation.

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