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Perineuronal nets of proteoglycans in the adult mouse brain are digested by collagenase.

Authors
  • Murakami, T
  • Murakami, T
  • Su, W D
  • Ohtsuka, A
  • Abe, K
  • Ninomiya, Y
Type
Published Article
Journal
Archives of histology and cytology
Publication Date
May 01, 1999
Volume
62
Issue
2
Pages
199–204
Identifiers
PMID: 10399544
Source
Medline
License
Unknown

Abstract

As our previous study has indicated, perineuronal proteoglycans in the adult mouse brain are associated with some collagenous molecules which can be stained with Gömöri's ammoniacal silver and are resistant to hyaluronidase digestion. The present study demonstrated that these molecules are thoroughly digested with collagenase, and suggests that they represent a hyaluronic acid-binding domain of the ligand proteoglycans connecting the perineuronal proteoglycans and nerve cell surface glycoproteins.

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