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Perinatal factors and 2-year minor neurodevelopmental impairment in low birth weight infants.

Authors
  • Spinillo, A
  • Fazzi, E
  • Orcesi, S
  • Accorsi, P
  • Beccaria, F
  • Capuzzo, E
Type
Published Article
Journal
Biology of the neonate
Publication Date
Jan 01, 1995
Volume
67
Issue
1
Pages
39–46
Identifiers
PMID: 7748974
Source
Medline
License
Unknown

Abstract

Perinatal factors were investigated in 53 low birth weight infants with minor neurodevelopmental dysfunction at 2-year follow-up and in 106 consecutive controls matched for gestational age and birth weight (within 100-gram intervals). The obstetrical history, as evaluated by the obstetrical optimality score, was significantly worse in the cases than in controls (obstetrical optimality score = 50.9 +/- 5.9 vs. 53.2 +/- 6.9, p = 0.019 by Mann-Whitney test). Multiple conditional logistic regression analysis showed that after adjustment for socioeconomic status and education of the mother, a low number (< 3) of prenatal visits, and a third trimester hemorrhage were the only antenatal factors significantly associated with an increased risk of minor infant neurodevelopmental impairment. Neonatal acidosis (pH < 7.2 in the first 24 h of life) and male gender were additional significant perinatal risk factors. Only a few antenatal and perinatal factors are correlated with subsequent minor neurodevelopmental impairment in low birth weight infants.

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