Affordable Access

deepdyve-link
Publisher Website

Perianal Paget's disease: case report and review of the literature.

Authors
  • Bontinck, H1
  • Bontinck, J1
  • Rondou, T2
  • Pattyn, P3
  • Lockefeer, F4
  • 1 a Department of General Surgery , Sint-Jozef Hospital , Bornem , Belgium. , (Belgium)
  • 2 b Department of Gastroenterology , Sint-Jozef Hospital , Bornem , Belgium. , (Belgium)
  • 3 c Department of Gastro-intestinal Surgery , Ghent University Hospital , Ghent , Belgium. , (Belgium)
  • 4 d Department of Pathology , Sint-Jozef Hospital , Bornem , Belgium. , (Belgium)
Type
Published Article
Journal
Acta Chirurgica Belgica
Publisher
Informa UK (Taylor & Francis)
Publication Date
Jun 01, 2016
Volume
116
Issue
3
Pages
187–192
Identifiers
DOI: 10.1080/00015458.2016.1139832
PMID: 27426653
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

A peri-anal skin lesion, often eczema-like and with symptoms of pruritus, that does not resolve after classical local therapy should be biopsied. We present a case of peri-anal extramammary Paget's disease (EMDP) and associated anal adenocarcinoma. Reviewing the literature, more than 30% of patients with EMDP present a second primary tumour in their past, present or future history. In Europe, the risk of developing a new primary tumour in patients with this condition is increased compared with the standard population. In cases of peri-anal Paget's disease (PPD), specific histochemical markers allow us to differentiate between a primary and a secondary form, the secondary one is strongly associated with colorectal and anal tumours. We provide information about the most commonly suggested therapy for PPD with or without associated malignancy and about the recommended follow-up.

Report this publication

Statistics

Seen <100 times