Affordable Access

deepdyve-link
Publisher Website

Performance of candidate urinary biomarkers for pancreatic cancer - Correlation with pancreatic cyst malignant progression?

Authors
  • Yip-Schneider, Michele T1
  • Soufi, Mazhar2
  • Carr, Rosalie A2
  • Flick, Katelyn F2
  • Wu, Huangbing2
  • Colgate, Cameron L3
  • Schmidt, C Max4
  • 1 Departments of Surgery, USA; Departments of Walther Oncology Center, USA; Departments of Indiana University Simon Cancer Center, USA; Departments of Indiana University Health Pancreatic Cyst and Cancer Early Detection Center, Indianapolis, IN, USA. , (India)
  • 2 Departments of Surgery, USA; Departments of Indiana University Health Pancreatic Cyst and Cancer Early Detection Center, Indianapolis, IN, USA. , (India)
  • 3 Departments of Center for Outcomes Research in Surgery, Indiana University School of Medicine, Indianapolis, IN, USA. , (India)
  • 4 Departments of Surgery, USA; Departments of Biochemistry/Molecular Biology, USA; Departments of Walther Oncology Center, USA; Departments of Indiana University Simon Cancer Center, USA; Departments of Indiana University Health Pancreatic Cyst and Cancer Early Detection Center, Indianapolis, IN, USA. Electronic address: [email protected] , (India)
Type
Published Article
Journal
American journal of surgery
Publication Date
Mar 01, 2020
Volume
219
Issue
3
Pages
492–495
Identifiers
DOI: 10.1016/j.amjsurg.2019.09.013
PMID: 31554598
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Intraductal papillary mucinous neoplasms (IPMN) are precursors of pancreatic cancer. Potential biomarkers of IPMN progression have not been identified in urine. A few urinary biomarkers were reported to be predictive of pancreatic ductal adenocarcinoma (PDAC). Here, we seek to assess their ability to detect high-risk IPMN. Urine was collected from patients undergoing pancreatic resection and healthy controls. TIMP-1(Tissue Inhibitor of Metalloproteinase-1), LYVE-1(Lymphatic Vessel Endothelial Receptor 1), and PGEM(Prostaglandin E Metabolite) levels were determined by ELISA and analyzed by Kruskal-Wallis. Median urinary TIMP-1 levels were significantly lower in healthy controls (n = 9; 0.32 ng/mg creatinine) compared to PDAC (n = 13; 1.95) but not significantly different between low/moderate-grade (n = 20; 0.71) and high-grade/invasive IPMN (n = 20; 1.12). No significant difference in urinary LYVE-1 was detected between IPMN low/moderate (n = 16; 0.37 ng/mg creatinine) and high/invasive grades (n = 21; 0.09). Urinary PGEM levels were not significantly different between groups. Urinary TIMP-1, LYVE-1, and PGEM do not correlate with malignant potential of pancreatic cysts. Copyright © 2019 Elsevier Inc. All rights reserved.

Report this publication

Statistics

Seen <100 times