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Perfecting DNA double-strand break repair on transcribed chromatin.

Authors
  • Tan, Xin Yi1
  • Huen, Michael S Y1, 2
  • 1 School of Biomedical Sciences, LKS Faculty of Medicine, The University of Hong Kong, 21 Sassoon Road, Pokfulam, Hong Kong S.A.R., China. , (China)
  • 2 State Key Laboratory of Brain and Cognitive Sciences, The University of Hong Kong, 5 Sassoon Road, Pokfulam, Hong Kong S.A.R., China. , (China)
Type
Published Article
Journal
Essays in biochemistry
Publication Date
Oct 26, 2020
Volume
64
Issue
5
Pages
705–719
Identifiers
DOI: 10.1042/EBC20190094
PMID: 32309851
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Timely repair of DNA double-strand break (DSB) entails coordination with the local higher order chromatin structure and its transaction activities, including transcription. Recent studies are uncovering how DSBs trigger transient suppression of nearby transcription to permit faithful DNA repair, failing of which leads to elevated chromosomal aberrations and cell hypersensitivity to DNA damage. Here, we summarize the molecular bases for transcriptional control during DSB metabolism, and discuss how the exquisite coordination between the two DNA-templated processes may underlie maintenance of genome stability and cell homeostasis. © 2020 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society.

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