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Percutaneous CT-guided sternal biopsy: factors affecting the diagnostic yield.

Authors
  • Song, Yoonah1
  • Kwon, Jong Won2, 3
  • 1 1 Department of Radiology, Hanyang University Hospital, Seoul, Republic of Korea. , (North Korea)
  • 2 2 Department of Radiology and Center for Imaging Science, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea. , (North Korea)
  • 3 3 Department of Medical Device Management & Research, SAIHST, Sungkyunkwan University, Seoul, Republic of Korea. , (North Korea)
Type
Published Article
Journal
Acta radiologica (Stockholm, Sweden : 1987)
Publication Date
Jul 01, 2017
Volume
58
Issue
7
Pages
825–833
Identifiers
DOI: 10.1177/0284185116676652
PMID: 27852642
Source
Medline
Keywords
License
Unknown

Abstract

Background Sternal lesions are occasionally seen in clinical practice and their diagnosis can be important, especially for oncologic patients. However, percutaneous computed tomography (CT)-guided biopsy of sternal lesions is rarely performed. Purpose To assess the diagnostic yield of percutaneous CT-guided sternal biopsies and to analyze the factors that affect diagnostic yield. Material and Methods A retrospective review of 34 patients who underwent CT-guided sternal biopsy was carried out at a single institution. Pre-biopsy CT density, location, penetration length of biopsy needle, number of biopsy attempts, angle of needle approach, final diagnosis, and operator experience level were recorded. A biopsy was considered as diagnostic if it provided a confident pathologic result. All variables were compared using Chi-square tests. Results Twenty-two of the 34 (64.7%) biopsy procedures yielded a diagnostic sample and 12 (35.3%) were non-diagnostic. Eight participants in the non-diagnostic group were clinically diagnosed with inflammatory arthritis of the manubriosternal or costosternal joints. Longer penetration distance of the tumor by the biopsy needle showed higher diagnostic yield ( P = 0.031). Osteoblastic lesions ( P < 0.001), lesions in the manubriosternal joint ( P = 0.018) and approaches using more obtuse angles ( P = 0.009) were associated with significantly lower diagnostic yields. Malignancy in the final diagnosis led to a higher diagnostic yield than benign lesions ( P < 0.001). Conclusion CT-guided percutaneous sternal biopsy has a relatively lower diagnostic yield. However, acute angle of needle approach may help increase biopsy success rate. Osteoblastic lesions and lesions in the manubriosternal joint tend to have lower diagnostic yield.

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