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Perception of quality of life in people experiencing or having experienced a Clostridioides difficile infection: a US population survey

  • Lurienne, Lise1
  • Bandinelli, Pierre-Alain1
  • Galvain, Thibaut1
  • Coursel, Charles-Alexis1
  • Oneto, Caterina2
  • Feuerstadt, Paul3, 4
  • 1 Da Volterra, 172 rue de Charonne, Paris, 75011, France , Paris (France)
  • 2 Concorde Medical Group, New York, USA , New York (United States)
  • 3 Yale School of Medicine, New Haven, CT, USA , New Haven (United States)
  • 4 Gastroenterology Center of Connecticut, Hamden, CT, USA , Hamden (United States)
Published Article
Journal of Patient-Reported Outcomes
Springer International Publishing
Publication Date
Feb 19, 2020
DOI: 10.1186/s41687-020-0179-1
Springer Nature


BackgroundAlthough the incidence, severity and mortality of Clostridioides (Clostridium) difficile infection (CDI) have been increasing, patients’ quality of life changes resulting from CDI have not been studied thoroughly. This study aimed at exploring the consequences of CDI on quality of life through patients’ perspective.MethodsAn observational, cross-sectional study involving 350 participants with a self-reported CDI diagnosis was conducted through an online self-administered survey. Participants were grouped into those who had active disease (“Current CDI”) and those who had a history of CDI (“Past CDI”).ResultsOne hundred fifteen participants (33%) reported Current CDI and 235 (67%) reported Past CDI. A large majority of participants admitted that their daily activities were impacted by the infection (93.9% and 64.7% of Current and Past CDI respondents respectively, p < 0.05). Physical and psychological consequences of CDI were experienced by 63.5% and 66.1% of participants with active CDI. Despite the infection being cleared, these consequences were still frequently experienced in Past CDI cohort with similar rates (reported by 73.2% of respondents for both, physical consequences p = 0.08; psychological consequences p = 0.21). After the infection, 56.6% of respondents noted that post-CDI symptoms remained; 40.9% believed they would never get rid of them.ConclusionsWhile the societal burden of CDI is well described in the literature, our study is one of the first aimed at understanding the major burden of CDI on quality of life. Our results highlight the long-lasting nature of CDI and further reinforce the need for enhanced therapeutics in the prevention and treatment of this devastating infection.

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