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Peptidomic Analysis of Maternal Serum to Identify Biomarker Candidates for Prenatal Diagnosis of Tetralogy of Fallot.

Authors
  • Zhuang, Bin1, 2
  • Hu, Yin1, 2
  • Fan, Xuemei3
  • Li, Mengmeng1
  • Zhu, Jingai1
  • Liu, Heng1, 2
  • Cao, Li4
  • Liang, Dong5
  • Zhang, Jingjing5
  • Yu, Zhangbin1
  • Han, Shuping1
  • 1 Department of Pediatrics, Obstetrics and Gynecology Hospital Affiliated to Nanjing Medical University, Nanjing, 210004, China. , (China)
  • 2 Fourth Clinical Medicine College, Nanjing Medical University, Nanjing, 210029, China. , (China)
  • 3 Department of Obstetrics, Obstetrics and Gynecology Hospital Affiliated to Nanjing Medical University, Nanjing, 210004, China. , (China)
  • 4 Department of Ultrasound, Obstetrics and Gynecology Hospital Affiliated to Nanjing Medical University, Nanjing, 210004, China. , (China)
  • 5 Department of Prenatal Diagnosis, Obstetrics and Gynecology Hospital Affiliated to Nanjing Medical University, Nanjing, 210004, China. , (China)
Type
Published Article
Journal
Journal of Cellular Biochemistry
Publisher
Wiley (John Wiley & Sons)
Publication Date
Jun 09, 2017
Identifiers
DOI: 10.1002/jcb.26204
PMID: 28598000
Source
Medline
Keywords
License
Unknown

Abstract

Tetralogy of Fallot (TOF) is the most common form of cyanotic congenital heart disease. To identify endogenous peptides possibly involved in the progression of TOF, we performed comparative peptidomic profiling of maternal serum between normal fetuses and fetuses suffering from TOF. A total of 278 differentially expressed peptides, including 94 over-expressed peptides and 184 under-expressed peptides, originating from 227 protein precursors were identified by liquid chromatography/mass spectrometry (LC/MS) in maternal serum of fetuses with TOF compared to normal controls. Further, ingenuity pathway analysis (IPA) was used to identify putative roles for these peptides in cardiovascular development. Two peptides were derived from functional domains of proteins involved in heart development and associated with TOF; these may represent candidate bioactive peptides involved in TOF. These peptides may be related to the pathologic changes in the heart associated with TOF, and may be useful as novel biomarkers for prenatal diagnosis of TOF. J. Cell. Biochem. 9999: 1-10, 2017. © 2017 Wiley Periodicals, Inc.

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