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Peptide inhibitor of morphine- and beta-endorphin-induced analgesia.

Authors
  • N M Lee
  • H J Friedman
  • L Leybin
  • T M Cho
  • H H Loh
  • C H Li
Publication Date
Sep 01, 1980
Source
PMC
Keywords
License
Unknown

Abstract

The synthetic beta-endorphin analogs with the omission of the NH2-terminal [Met]enkephalin segment [beta-endorphin-(6-31) and beta-endorphin-(20-31)] are shown to inhibit morphine- or beta-endorphin-induced analgesia in mice by the tail-flick test, whereas the synthetic NH2-terminal pentadecapeptide beta-endorphin-(1-15) has no inhibitory activity. This study raises the possibility that endogenous inhibiting peptides exist in the brain which play a role in the regulation of endorphin actions.

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