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A peptide corresponding to the N-terminal 13 residues of T4 lysozyme forms an alpha-helix.

Authors
  • McLeish, M J
  • Nielsen, K J
  • Wade, J D
  • Craik, D J
Type
Published Article
Journal
FEBS Letters
Publisher
Wiley (John Wiley & Sons)
Publication Date
Jan 11, 1993
Volume
315
Issue
3
Pages
323–328
Identifiers
PMID: 8422925
Source
Medline
License
Unknown

Abstract

Solid-phase methods have been used to synthesize LYS(1-13), a peptide corresponding to the first 13 residues of T4 lysozyme. 2D 1H NMR techniques were used to investigate its solution structure in the presence of SDS micelles. The identification of numerous medium-range NOESY crosspeaks and several slowly exchanging NH protons indicated the presence of an alpha-helical structure. This was confirmed by simulated annealing calculations performed using XPLOR.

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