Affordable Access

Access to the full text

Pepsin in Saliva as a Diagnostic Marker for Gastroesophageal Reflux Disease: A Meta-Analysis

Authors
  • Guo, Zihao1
  • Wu, Hao2
  • Jiang, Jiali1
  • Zhang, Chuan1
  • 1 Department of Gastroenterology, Beijing Tong Ren Hospital, Capital Medical University, Beijing, P.R. China
  • 2 Department of Cardiovascular, Beijing Tong Ren Hospital, Capital Medical University, Beijing, P.R. China
Type
Published Article
Journal
Medical Science Monitor
Publisher
"International Scientific Information, Inc."
Publication Date
Dec 31, 2018
Volume
24
Pages
9509–9516
Identifiers
DOI: 10.12659/MSM.913978
PMID: 30596632
PMCID: PMC6324865
Source
PubMed Central
Keywords
License
Green

Abstract

Background Gastroesophageal reflux disease (GERD) is very common. Salivary pepsin detection has previously been considered as a method for GERD diagnosis. We performed a meta-analysis to investigate the utility of salivary pepsin assay as a diagnostic tool of GERD. Material/Methods PubMed, Web of Science, the Cochran Library, and EMBASE (from January 1980 to 23 October 2018) were searched for pepsin in saliva for GERD diagnosis. We summarized the retrieved specificity, sensitivity, negative likelihood ratio (NLR), positive likelihood ratio (PLR), diagnostic odds ratio (DOR), and receiver operating characteristic (ROC) curves data in the meta-analysis. Results In final analysis, a total of 5 studies were included. The summary sensitivity, specificity, NLR, and PLR were 0.60 (95% CI 0.41–0.76), 0.71 (95% CI 0.51–0.86), 0.56 (95% CI 0.34–0.93), and 2.1 (95% CI 1.1–4.1), respectively. The pooled DOR was 4 (95% CI 1.0–11.0) and area under the ROC was 0.70 (95% CI 0.66–0.74). Conclusions The meta-analysis showed that pepsin in saliva has moderate diagnostic value for GERD, and is not as helpful as previously thought.

Report this publication

Statistics

Seen <100 times