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Pepsin 1 secretion in chronic peptic ulceration.

Authors
  • Walker, V
  • Taylor, W H
Type
Published Article
Journal
Gut
Publication Date
Sep 01, 1980
Volume
21
Issue
9
Pages
766–771
Identifiers
PMID: 6776016
Source
Medline
License
Unknown

Abstract

In patients with peptic ulceration, both vagal stimulation by insulin hypoglycaemia and stimulation by pentagastrin cause pepsin 1 to be secreted into gastric juice. There is a secretory threshold for pepsin 1, below which only pepsins 3 and 5 are secreted. Pepsin 1 accounts for an increasing proportion of the total peptic activity/ml of gastric juice as the total activity increases. Higher concentrations of pepsin 1 in the basal gastric secretion occurred significantly more frequently in patients with duodenal ulcer than with gastric ulcer. In these patients there may be an increased 'background' secretory drive.

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