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People of the British Isles: preliminary analysis of genotypes and surnames in a UK-control population.

Authors
  • Winney, Bruce1
  • Boumertit, Abdelhamid
  • Day, Tammy
  • Davison, Dan
  • Echeta, Chikodi
  • Evseeva, Irina
  • Hutnik, Katarzyna
  • Leslie, Stephen
  • Nicodemus, Kristin
  • Royrvik, Ellen C
  • Tonks, Susan
  • Yang, Xiaofeng
  • Cheshire, James
  • Longley, Paul
  • Mateos, Pablo
  • Groom, Alexandra
  • Relton, Caroline
  • Bishop, D Tim
  • Black, Kathryn
  • Northwood, Emma
  • And 11 more
  • 1 Department of Oncology, University of Oxford, ORCRB, Headington, Oxford, UK. [email protected]
Type
Published Article
Journal
European Journal of Human Genetics
Publisher
Springer Nature
Publication Date
Feb 01, 2012
Volume
20
Issue
2
Pages
203–210
Identifiers
DOI: 10.1038/ejhg.2011.127
PMID: 21829225
Source
Medline
License
Unknown

Abstract

There is a great deal of interest in a fine-scale population structure in the UK, both as a signature of historical immigration events and because of the effect population structure may have on disease association studies. Although population structure appears to have a minor impact on the current generation of genome-wide association studies, it is likely to have a significant part in the next generation of studies designed to search for rare variants. A powerful way of detecting such structure is to control and document carefully the provenance of the samples involved. In this study, we describe the collection of a cohort of rural UK samples (The People of the British Isles), aimed at providing a well-characterised UK-control population that can be used as a resource by the research community, as well as providing a fine-scale genetic information on the British population. So far, some 4000 samples have been collected, the majority of which fit the criteria of coming from a rural area and having all four grandparents from approximately the same area. Analysis of the first 3865 samples that have been geocoded indicates that 75% have a mean distance between grandparental places of birth of 37.3 km, and that about 70% of grandparental places of birth can be classed as rural. Preliminary genotyping of 1057 samples demonstrates the value of these samples for investigating a fine-scale population structure within the UK, and shows how this can be enhanced by the use of surnames.

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